Scientists Crack The Negative Code: Discover Brain Region That Controls Feelings Of Disappointment 

Scientists at the University of California, San Francisco, have identified a new and previously unknown pattern of brain activity that might help develop new therapies to treat mood disorders or depression in the future.

A control mechanism has been found in an area of the brain that processes sensory and emotional information that humans experience, commonly termed as ‘disappointment’.

Roberto Malinwo said, "The reason behind some people noticing only the negatives in the world first is because of a chemical basis in the brain". He is a professor in the Department of Neurosciences and Neurobiology wing of the Division of Biological Sciences, reports India Today.

People suffering from depression are observed to be more sensitive about negative experiences. This study is one of its kind since it ventures to understand that the same brain pathway can capture the feelings of inhibition and excitation together.

The functioning of LHb (luteinizing hormone beta polypeptide) is believed to be of a greater importance than just a causal agent of disappointment, it also releases pain responses and triggers various motivational behaviours.

Depression has been linked with the hyperactivity of the LHb. With this study, the researchers might now have a precise neurochemical explanation for resilient effect of antidepressants on some people.